Oral health is a core component of overall health; a healthy mouth and a healthy body are bidirectionally related. An umbrella review shows that, as of 2022, researchers had published 293 systematic reviews with meta-analyses on the links between oral diseases and noncommunicable diseases (e.g., diabetes, cardiovascular disease, depression).1 Oral diseases and systemic diseases are connected in a way that is consistent with a life course approach, with risk factors and health outcomes changing throughout the life span. Evaluating OSI through this lens allows us to better understand potential links between risk exposure and subsequent disease development as, in part, a function of an individual’s age. As we look across the life span, we discover how physical, emotional, environmental, and social aspects of life relate to OSI. As our understanding of OSI increases, the importance of integrating medicine and dentistry for care across the life span becomes increasingly clear. MDI is an essential component  of achieving overall health that is inclusive of oral health.  MDI models are complex to design, are implemented with varying degrees of success, and yield benefits such as improved interprofessional communications and better health care outcomes. This report discusses the need to understand a life course approach regarding both OSI and MDI. It provides a comprehensive overview of the bidirectional nature of oral and systemic diseases across different life phases and how health care delivery in an integrated form can improve access to care and health outcomes. Finally, it discusses the gaps, challenges, and barriers to creating integrated models, and provides recommendations to improve the future of MDI.